Specialised proteins direct migrating cells and axons through the developing body. They guide the formation of complex tissues such as the neural and vascular networks. Understanding how these tissues form is important, because failure leads to neurodevelopmental diseases and cancers.
A multidisciplinary approach
The lab uses a range of cutting-edge techniques, especially X-ray crystallography, electron microscopy, cell biology assays, confocal and super resolution microscopy. Combining these techniques allows us to understand how cell guidance receptors function on the molecular, cellular and tissue levels.