Cell guidance during tissue development relies on a combinatorial code of receptor and ligand interactions that direct adhesive/attractive and repulsive cellular responses. Depending on the context, these interactions give rise to distinct molecular assemblies with unique functional properties. Understanding the rules governing the assembly of these receptor-ligand complexes requires detailed knowledge of their structures and signalling properties. The lab's recent focus is on the distinct and emerging class of adhesion G-protein-coupled receptors (adhesion GPCRs), which contain large extracellular domains that mediate cell-cell and cell-matrix interactions, and their interacting ligands. Adhesion GPCRs are key to human biology and are involved in specific developmental diseases and cancers. We aim to reveal fundamental structural and functional mechanisms by which adhesion GPCRs and their interactions control relevant biological processes, with a particular focus on the neural and vascular systems.